Brief Report: Airways abnormalities and rheumatoid arthritis–related autoantibodies in subjects without arthritis: Early injury or initiating site of autoimmunity?
Identifieur interne : 001420 ( Main/Exploration ); précédent : 001419; suivant : 001421Brief Report: Airways abnormalities and rheumatoid arthritis–related autoantibodies in subjects without arthritis: Early injury or initiating site of autoimmunity?
Auteurs : M. Kristen Demoruelle ; Michael H. Weisman [États-Unis] ; Philip L. Simonian ; David A. Lynch [États-Unis] ; Peter B. Sachs ; Isabel F. Pedraza [États-Unis] ; Annie R. Harrington [États-Unis] ; Jason R. Kolfenbach ; Christopher C. Striebich ; Quyen N. Pham [États-Unis] ; Colin D. Strickland ; Brian D. Petersen ; Mark C. Parish ; Lezlie A. Derber ; Jill M. Norris ; V. Michael Holers ; Kevin D. Deane [États-Unis]Source :
- Arthritis & Rheumatism [ 0004-3591 ] ; 2012-06.
Abstract
Objective: To evaluate the presence of pulmonary abnormalities in rheumatoid arthritis (RA)–related autoantibody–positive subjects without inflammatory arthritis. Methods: Forty‐two subjects who did not have inflammatory arthritis but were positive for anti–cyclic citrullinated peptide antibodies and/or ≥2 rheumatoid factor isotypes (a profile that is 96% specific for RA), 15 autoantibody‐negative controls, and 12 patients with established seropositive early RA (<1‐year duration) underwent spirometry and high‐resolution computed tomography (HRCT) lung imaging. Results: The median age of autoantibody‐positive subjects was 54 years, 52% were female, and 38% were ever‐smokers; these characteristics were not significantly different from those of autoantibody‐negative control subjects. No autoantibody‐positive subject had inflammatory arthritis based on joint examination. HRCT revealed that 76% of autoantibody‐positive subjects had airways abnormalities including bronchial wall thickening, bronchiectasis, centrilobular opacities, and air trapping, compared with 33% of autoantibody‐negative controls (P = 0.005). The prevalence and type of lung abnormalities among autoantibody‐positive subjects were similar to those among patients with early RA. In 2 autoantibody‐positive subjects with airways disease, inflammatory arthritis classifiable as articular RA developed ∼13 months after the lung evaluation. Conclusion: Airways abnormalities that are consistent with inflammation are common in autoantibody‐positive subjects without inflammatory arthritis and are similar to airways abnormalities seen in patients with early RA. These findings suggest that the lung may be an early site of autoimmune‐related injury and potentially a site of generation of RA‐related autoimmunity. Further studies are needed to define the mechanistic role of lung inflammation in the development of RA.
Url:
DOI: 10.1002/art.34344
Affiliations:
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Kristen" last="Demoruelle">M. Kristen Demoruelle</name><affiliation><wicri:noCountry code="subField">Aurora</wicri:noCountry></affiliation></author><author><name sortKey="Weisman, Michael H" sort="Weisman, Michael H" uniqKey="Weisman M" first="Michael H." last="Weisman">Michael H. Weisman</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Cedars‐Sinai Medical Center, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Simonian, Philip L" sort="Simonian, Philip L" uniqKey="Simonian P" first="Philip L." last="Simonian">Philip L. Simonian</name><affiliation><wicri:noCountry code="subField">Aurora</wicri:noCountry></affiliation></author><author><name sortKey="Lynch, David A" sort="Lynch, David A" uniqKey="Lynch D" first="David A." last="Lynch">David A. Lynch</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Colorado</region></placeName><wicri:cityArea>National Jewish Health, Denver</wicri:cityArea></affiliation></author><author><name sortKey="Sachs, Peter B" sort="Sachs, Peter B" uniqKey="Sachs P" first="Peter B." last="Sachs">Peter B. Sachs</name><affiliation><wicri:noCountry code="subField">Aurora</wicri:noCountry></affiliation></author><author><name sortKey="Pedraza, Isabel F" sort="Pedraza, Isabel F" uniqKey="Pedraza I" first="Isabel F." last="Pedraza">Isabel F. Pedraza</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Cedars‐Sinai Medical Center, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Harrington, Annie R" sort="Harrington, Annie R" uniqKey="Harrington A" first="Annie R." last="Harrington">Annie R. Harrington</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Cedars‐Sinai Medical Center, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Kolfenbach, Jason R" sort="Kolfenbach, Jason R" uniqKey="Kolfenbach J" first="Jason R." last="Kolfenbach">Jason R. Kolfenbach</name><affiliation><wicri:noCountry code="subField">Aurora</wicri:noCountry></affiliation></author><author><name sortKey="Striebich, Christopher C" sort="Striebich, Christopher C" uniqKey="Striebich C" first="Christopher C." last="Striebich">Christopher C. Striebich</name><affiliation><wicri:noCountry code="subField">Aurora</wicri:noCountry></affiliation></author><author><name sortKey="Pham, Quyen N" sort="Pham, Quyen N" uniqKey="Pham Q" first="Quyen N." last="Pham">Quyen N. Pham</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Colorado</region></placeName><wicri:cityArea>Exempla St. Joseph Hospital, Denver</wicri:cityArea></affiliation></author><author><name sortKey="Strickland, Colin D" sort="Strickland, Colin D" uniqKey="Strickland C" first="Colin D." last="Strickland">Colin D. Strickland</name><affiliation><wicri:noCountry code="subField">Aurora</wicri:noCountry></affiliation></author><author><name sortKey="Petersen, Brian D" sort="Petersen, Brian D" uniqKey="Petersen B" first="Brian D." last="Petersen">Brian D. Petersen</name><affiliation><wicri:noCountry code="subField">Aurora</wicri:noCountry></affiliation></author><author><name sortKey="Parish, Mark C" sort="Parish, Mark C" uniqKey="Parish M" first="Mark C." last="Parish">Mark C. Parish</name><affiliation><wicri:noCountry code="subField">Aurora</wicri:noCountry></affiliation></author><author><name sortKey="Derber, Lezlie A" sort="Derber, Lezlie A" uniqKey="Derber L" first="Lezlie A." last="Derber">Lezlie A. Derber</name><affiliation><wicri:noCountry code="subField">Aurora</wicri:noCountry></affiliation></author><author><name sortKey="Norris, Jill M" sort="Norris, Jill M" uniqKey="Norris J" first="Jill M." last="Norris">Jill M. Norris</name><affiliation><wicri:noCountry code="subField">Aurora</wicri:noCountry></affiliation></author><author><name sortKey="Holers, V Michael" sort="Holers, V Michael" uniqKey="Holers V" first="V. Michael" last="Holers">V. Michael Holers</name><affiliation><wicri:noCountry code="subField">Aurora</wicri:noCountry></affiliation></author><author><name sortKey="Deane, Kevin D" sort="Deane, Kevin D" uniqKey="Deane K" first="Kevin D." last="Deane">Kevin D. Deane</name><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Colorado</region></placeName><wicri:cityArea>Correspondence address: Division of Rheumatology, University of Colorado School of Medicine, 1775 Aurora Court, Mail Stop B‐115, Aurora</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Arthritis & Rheumatism</title><title level="j" type="alt">ARTHRITIS AND RHEUMATISM</title><idno type="ISSN">0004-3591</idno><idno type="eISSN">1529-0131</idno><imprint><biblScope unit="vol">64</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1756">1756</biblScope><biblScope unit="page" to="1761">1761</biblScope><biblScope unit="page-count">6</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2012-06">2012-06</date></imprint><idno type="ISSN">0004-3591</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0004-3591</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: To evaluate the presence of pulmonary abnormalities in rheumatoid arthritis (RA)–related autoantibody–positive subjects without inflammatory arthritis. Methods: Forty‐two subjects who did not have inflammatory arthritis but were positive for anti–cyclic citrullinated peptide antibodies and/or ≥2 rheumatoid factor isotypes (a profile that is 96% specific for RA), 15 autoantibody‐negative controls, and 12 patients with established seropositive early RA (<1‐year duration) underwent spirometry and high‐resolution computed tomography (HRCT) lung imaging. Results: The median age of autoantibody‐positive subjects was 54 years, 52% were female, and 38% were ever‐smokers; these characteristics were not significantly different from those of autoantibody‐negative control subjects. No autoantibody‐positive subject had inflammatory arthritis based on joint examination. HRCT revealed that 76% of autoantibody‐positive subjects had airways abnormalities including bronchial wall thickening, bronchiectasis, centrilobular opacities, and air trapping, compared with 33% of autoantibody‐negative controls (P = 0.005). The prevalence and type of lung abnormalities among autoantibody‐positive subjects were similar to those among patients with early RA. In 2 autoantibody‐positive subjects with airways disease, inflammatory arthritis classifiable as articular RA developed ∼13 months after the lung evaluation. Conclusion: Airways abnormalities that are consistent with inflammation are common in autoantibody‐positive subjects without inflammatory arthritis and are similar to airways abnormalities seen in patients with early RA. These findings suggest that the lung may be an early site of autoimmune‐related injury and potentially a site of generation of RA‐related autoimmunity. Further studies are needed to define the mechanistic role of lung inflammation in the development of RA.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Colorado</li></region></list><tree><noCountry><name sortKey="Demoruelle, M Kristen" sort="Demoruelle, M Kristen" uniqKey="Demoruelle M" first="M. Kristen" last="Demoruelle">M. Kristen Demoruelle</name><name sortKey="Derber, Lezlie A" sort="Derber, Lezlie A" uniqKey="Derber L" first="Lezlie A." last="Derber">Lezlie A. Derber</name><name sortKey="Holers, V Michael" sort="Holers, V Michael" uniqKey="Holers V" first="V. Michael" last="Holers">V. Michael Holers</name><name sortKey="Kolfenbach, Jason R" sort="Kolfenbach, Jason R" uniqKey="Kolfenbach J" first="Jason R." last="Kolfenbach">Jason R. Kolfenbach</name><name sortKey="Norris, Jill M" sort="Norris, Jill M" uniqKey="Norris J" first="Jill M." last="Norris">Jill M. Norris</name><name sortKey="Parish, Mark C" sort="Parish, Mark C" uniqKey="Parish M" first="Mark C." last="Parish">Mark C. Parish</name><name sortKey="Petersen, Brian D" sort="Petersen, Brian D" uniqKey="Petersen B" first="Brian D." last="Petersen">Brian D. Petersen</name><name sortKey="Sachs, Peter B" sort="Sachs, Peter B" uniqKey="Sachs P" first="Peter B." last="Sachs">Peter B. Sachs</name><name sortKey="Simonian, Philip L" sort="Simonian, Philip L" uniqKey="Simonian P" first="Philip L." last="Simonian">Philip L. Simonian</name><name sortKey="Strickland, Colin D" sort="Strickland, Colin D" uniqKey="Strickland C" first="Colin D." last="Strickland">Colin D. Strickland</name><name sortKey="Striebich, Christopher C" sort="Striebich, Christopher C" uniqKey="Striebich C" first="Christopher C." last="Striebich">Christopher C. Striebich</name></noCountry><country name="États-Unis"><region name="Californie"><name sortKey="Weisman, Michael H" sort="Weisman, Michael H" uniqKey="Weisman M" first="Michael H." last="Weisman">Michael H. Weisman</name></region><name sortKey="Deane, Kevin D" sort="Deane, Kevin D" uniqKey="Deane K" first="Kevin D." last="Deane">Kevin D. Deane</name><name sortKey="Deane, Kevin D" sort="Deane, Kevin D" uniqKey="Deane K" first="Kevin D." last="Deane">Kevin D. Deane</name><name sortKey="Harrington, Annie R" sort="Harrington, Annie R" uniqKey="Harrington A" first="Annie R." last="Harrington">Annie R. Harrington</name><name sortKey="Lynch, David A" sort="Lynch, David A" uniqKey="Lynch D" first="David A." last="Lynch">David A. Lynch</name><name sortKey="Pedraza, Isabel F" sort="Pedraza, Isabel F" uniqKey="Pedraza I" first="Isabel F." last="Pedraza">Isabel F. Pedraza</name><name sortKey="Pham, Quyen N" sort="Pham, Quyen N" uniqKey="Pham Q" first="Quyen N." last="Pham">Quyen N. 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